Antimalarial activity from three ascidians: an exploration of different marine invertebrate phyla
Identifieur interne : 001C28 ( Main/Exploration ); précédent : 001C27; suivant : 001C29Antimalarial activity from three ascidians: an exploration of different marine invertebrate phyla
Auteurs : Judith Mendiola [Cuba] ; Hilda Hernández [Cuba] ; Idalia Sariego [Cuba] ; Lázara Rojas [Cuba] ; Anabel Otero [Cuba] ; Angel Ramírez [Cuba] ; María De Los Angeles Chávez [Cuba] ; Juan Abreu Payrol [Cuba] ; Aida Hernández [Cuba]Source :
- Transactions of The Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 2006.
Abstract
Recent research suggests that marine organisms may produce compounds with activity against malaria parasites. Of a total of 27 aqueous extracts from different marine species, collected on the northwest Cuban coast, 20 were considered as showing no significant activity against Plasmodium falciparum F32, with minimum inhibitory concentrations (MIC) >500 μg/ml, while seven extracts (MIC ≤500 μg/ml) were selected for further investigation by determining their selectivity indices and in vivo antimalarial activity. Three species of tunicates were chosen, as more than 50% reduction of P. berghei parasitaemia was produced after administration of 250 or 500 mg/kg of their crude extracts into infected mice. The aqueous extracts of Microcosmus goanus, Ascidia sydneiensis and Phallusia nigra were partitioned between water and n-butanol; the organic phases inhibited P. falciparum growth by 50% at concentrations of 17.5 μg/ml, 20.9 μg/ml and 29.4 μg/ml respectively. In general, these results are similar to those of most ethnobotanical surveys. Further chemical studies are being undertaken in order to isolate new antimalarial compounds from these Caribbean tunicates.
Url:
DOI: 10.1016/j.trstmh.2005.11.013
Affiliations:
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Box 601, Marianao 13, Ciudad Habana</wicri:regionArea><wicri:noRegion>Ciudad Habana</wicri:noRegion></affiliation></author><author><name sortKey="Otero, Anabel" sort="Otero, Anabel" uniqKey="Otero A" first="Anabel" last="Otero">Anabel Otero</name><affiliation wicri:level="1"><country xml:lang="fr">Cuba</country><wicri:regionArea>Faculty of Biology, University of Havana, 25 y J, Vedado, Ciudad Habana</wicri:regionArea><wicri:noRegion>Ciudad Habana</wicri:noRegion></affiliation></author><author><name sortKey="Ramirez, Angel" sort="Ramirez, Angel" uniqKey="Ramirez A" first="Angel" last="Ramírez">Angel Ramírez</name><affiliation wicri:level="1"><country xml:lang="fr">Cuba</country><wicri:regionArea>Faculty of Biology, University of Havana, 25 y J, Vedado, Ciudad Habana</wicri:regionArea><wicri:noRegion>Ciudad Habana</wicri:noRegion></affiliation></author><author><name sortKey="De Los Angeles Chavez, Maria" sort="De Los Angeles Chavez, Maria" uniqKey="De Los Angeles Chavez M" first="María" last="De Los Angeles Chávez">María De Los Angeles Chávez</name><affiliation wicri:level="1"><country xml:lang="fr">Cuba</country><wicri:regionArea>Faculty of Biology, University of Havana, 25 y J, Vedado, Ciudad Habana</wicri:regionArea><wicri:noRegion>Ciudad Habana</wicri:noRegion></affiliation></author><author><name sortKey="Payrol, Juan Abreu" sort="Payrol, Juan Abreu" uniqKey="Payrol J" first="Juan Abreu" last="Payrol">Juan Abreu Payrol</name><affiliation wicri:level="1"><country xml:lang="fr">Cuba</country><wicri:regionArea>Institute of Pharmacy and Food, University of Havana, Ave 23 #21422, La Coronela, La Lisa, Ciudad Habana</wicri:regionArea><wicri:noRegion>Ciudad Habana</wicri:noRegion></affiliation></author><author><name sortKey="Hernandez, Aida" sort="Hernandez, Aida" uniqKey="Hernandez A" first="Aida" last="Hernández">Aida Hernández</name><affiliation wicri:level="1"><country xml:lang="fr">Cuba</country><wicri:regionArea>Institute for Marine Science, CITMA, Ave 1ra # 18406 e/184 y 186, Rpto Flores, Playa, Ciudad Habana</wicri:regionArea><wicri:noRegion>Ciudad Habana</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Transactions of The Royal Society of Tropical Medicine and Hygiene</title><title level="j" type="abbrev">Trans R Soc Trop Med Hyg</title><idno type="ISSN">0035-9203</idno><idno type="eISSN">1878-3503</idno><imprint><publisher>Royal Society of Tropical Medicine and Hygiene</publisher><date when="2006-10">2006</date><biblScope unit="vol">100</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="909">909</biblScope><biblScope unit="page" to="916">916</biblScope></imprint><idno type="ISSN">0035-9203</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0035-9203</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Recent research suggests that marine organisms may produce compounds with activity against malaria parasites. Of a total of 27 aqueous extracts from different marine species, collected on the northwest Cuban coast, 20 were considered as showing no significant activity against Plasmodium falciparum F32, with minimum inhibitory concentrations (MIC) >500 μg/ml, while seven extracts (MIC ≤500 μg/ml) were selected for further investigation by determining their selectivity indices and in vivo antimalarial activity. Three species of tunicates were chosen, as more than 50% reduction of P. berghei parasitaemia was produced after administration of 250 or 500 mg/kg of their crude extracts into infected mice. The aqueous extracts of Microcosmus goanus, Ascidia sydneiensis and Phallusia nigra were partitioned between water and n-butanol; the organic phases inhibited P. falciparum growth by 50% at concentrations of 17.5 μg/ml, 20.9 μg/ml and 29.4 μg/ml respectively. In general, these results are similar to those of most ethnobotanical surveys. Further chemical studies are being undertaken in order to isolate new antimalarial compounds from these Caribbean tunicates.</div></front></TEI><affiliations><list><country><li>Cuba</li></country></list><tree><country name="Cuba"><noRegion><name sortKey="Mendiola, Judith" sort="Mendiola, Judith" uniqKey="Mendiola J" first="Judith" last="Mendiola">Judith Mendiola</name></noRegion><name sortKey="De Los Angeles Chavez, Maria" sort="De Los Angeles Chavez, Maria" uniqKey="De Los Angeles Chavez M" first="María" last="De Los Angeles Chávez">María De Los Angeles Chávez</name><name sortKey="Hernandez, Aida" sort="Hernandez, Aida" uniqKey="Hernandez A" first="Aida" last="Hernández">Aida Hernández</name><name sortKey="Hernandez, Hilda" sort="Hernandez, Hilda" uniqKey="Hernandez H" first="Hilda" last="Hernández">Hilda Hernández</name><name sortKey="Mendiola, Judith" sort="Mendiola, Judith" uniqKey="Mendiola J" first="Judith" last="Mendiola">Judith Mendiola</name><name sortKey="Otero, Anabel" sort="Otero, Anabel" uniqKey="Otero A" first="Anabel" last="Otero">Anabel Otero</name><name sortKey="Payrol, Juan Abreu" sort="Payrol, Juan Abreu" uniqKey="Payrol J" first="Juan Abreu" last="Payrol">Juan Abreu Payrol</name><name sortKey="Ramirez, Angel" sort="Ramirez, Angel" uniqKey="Ramirez A" first="Angel" last="Ramírez">Angel Ramírez</name><name sortKey="Rojas, Lazara" sort="Rojas, Lazara" uniqKey="Rojas L" first="Lázara" last="Rojas">Lázara Rojas</name><name sortKey="Sariego, Idalia" sort="Sariego, Idalia" uniqKey="Sariego I" first="Idalia" last="Sariego">Idalia Sariego</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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